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Spindle assembly checkpoint1/2/2024 ![]() During metaphase, MAD1 and BUB1 monitor proper spindle microtubule-kinetochore attachment/tension. The SAC is composed of several members that are conserved from yeast to mammals the core components include MAD1, MAD2, MAD3 (BUBR1 in mammals), BUB1 and BUB3. The SAC is best characterized for its role in preventing premature separation of sister chromatids until proper chromosome alignment has been achieved at the metaphase-to-anaphase transition. Once the genome is duplicated, proper chromosome segregation is ensured by the spindle assembly checkpoint (SAC). Here we review recent findings demonstrating overlapping roles for the SAC and DDR in metaphase, and in response to DNA damage throughout the cell cycle.Ĭell cycle checkpoint chromosome segregation DNA damage spindle assemblyįor successful cell division, the genome must be accurately duplicated and equally segregated into daughter cells, which requires exquisite kinetics and regulation. There have been extensive studies characterizing the roles of these checkpoints in response to the processes for which they are named however, emerging evidence suggests significant crosstalk between the checkpoints. The DDR monitors DNA lesions in G1, S, and G2 stages of the cell cycle and the SAC ensures proper chromosome segregation in M phase. Consequently, genome integrity is monitored by two major checkpoints, the DNA damage response (DDR) and the spindle assembly checkpoint (SAC). Lawrence and JoAnne Engebrecht* Department of Molecular and Cellular Biology, University of California Davis, One Shields Ave, Davis, California 95616, USAĪbstract Genome stability is essential for cell proliferation and survival. The spindle assembly checkpoint: More than just keeping track of the spindle Katherine S. Published in final edited form as: Trends Cell Mol Biol. Author manuscript available in PMC 2016 September 22. ![]() HHS Public Access Author manuscript Author Manuscript
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